Editorial: The Challenge of New Therapeutic Approaches for Unmet Therapeutic Needs

Unmet therapeutic needs for uterine myomas.

Uterine myomas may develop in many women, but only become clinically significant in about one third of the affected population. Although uterine myomas are most often benign, they are associated with debilitating symptoms and commonly result in hysterectomy. Current treatments for uterine myomas include pharmacologic therapies, delivery of focused energy, alteration of uterine vascular supply, ...

Unmet therapeutic needs in the new era of combination antiretroviral therapy for HIV-1.

Significant advances in outcomes have been achieved with combination antiretroviral therapy (cART) in patients living with HIV. However, several ongoing needs remain with respect to the development of new treatments. The need for new or enhanced cART may become increasingly apparent as patients live longer with HIV and a greater proportion die from non-AIDS-related illnesses. Immunological resp...

Editorial: Unmet Needs in Dystonia

[Lymphangioleiomyomatosis: new therapeutic approaches].

Lymphangioleiomyomatosis (LAM) is a rare disease that affects young women of child-bearing age. It is characterized by the presence of cystic changes in the pulmonary parenchyma, repeated pneumothorax, chylothorax and renal angiomyolipomas, and in the majority of cases it is accompanied by a progressive loss in lung function.1 In the last two decades, there has been an increase in the understan...

Review of Therapeutic Candidates for the New Coronavirus disease (COVID19)

Background: COVID-19 infectious disease caused by the sever acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurred in late November 2019 in Wuhan, China and has become a worldwide health crisis. The World Health Organization has identified COVID-19 as a public health priority of international concern. This is because the epidemic has become a pandemic and there is no effective antiviral...